ANTI-NOCICEPTIVE OUTCOMES OF ANTICONVULSANT/ANTIDEPRESSANT MEDICINES IN THE MANAGEMENT OF FORMALIN INDUCED PAIN IN GROUP OF MICE

Abstract

Background: Anti-depressant are used to treat various disorders like neuropathic pain, migraine etc. Anticonvulsant drugs may have a role in the modulation of changes include inhibition of voltage gated ion channels at sites of spinal, supraspinal and peripheral.

Objectives: An experimental observational study was carried out to find the role of anti-nociceptive outcomes of anticonvulsant/antidepressant medicines in the management of formalin induced pain in group of mice.

Methods: A total of 20 albino mice weighed 20-30 gm. were taken from animal dwelling of The University of Lahore. Formalin induced pain was judged by observing the lifting of paw and behavior. Animals were divided in 4 groups (five mice in each group) group no 1: Control, group no 2: Paracetamol, group no 3: Fluvoxamine, group no 4: Lamotrigine.  After given the doses of drugs, 5.0 % formalin solution was injected. Number of counts of licking paw and paw-lifting of mice during first phase and second phase was noted. Percentage effectiveness was calculated by the formula.

The palliative action of the medicine was evaluated by calculating the latency moment in reaction to stimulus of heat. The animals were positioned on hot plate at time interval zero min, 30 min, 60 min and 90 min subsequent the administration of medicine. The Latency time until animal began either jumping or licking was noted. Percentage of maximum possible effects (MPE) is calculated by formula.

Conclusion: Our study shows the anti-nociceptive outcomes of fluvoxamine & lamotrigine in the management of formalin induced pain in group of mice