PROTECTIVE ROLE OF CURCUMIN AGAINST ASPIRIN INDUCED TOXICITY OF PROXIMAL CONVOLUTED TUBULE IN ALBINO RATS

Abstract

Aspirin is a well known anti-inflammatory, analgesic and anti-pyretic drug. Turmeric powder commonly known as “Haldi” has an active ingredient curcumin which is being widely used in ayurvedic medicine. Objective: To determine the nephroprotective role of curcumin on dose related nephrotoxicity induced by aspirin in adult albino rats. Study design: It was Experimental. Material and Methods: We divided the rats into four groups, 15 rats in each. The duration of study was 30 days. The rats were given 200 mg/kg body weight of aspirin through orogastric catheter to induce toxicity in kidneys of group B (positive control) and groups C and D (experimental). The rats of groups C & D also received 15 mg/kg & 30 mg/kg body weight of curcumin alongwith toxic dose of aspirin through orogastric catheter. Results: Current study depicted that groups B, C & D showed smaller diameters of the PCT (proximal convoluted tubules) in comparison with group A. The effects in diameters were dose related. The difference among the groups showed highly significant p-value <0.001. (Table.1) Conclusion: The results of current research have proved the nephroprotective ability of curcumin is by its antioxidant properties due to a counteraction of free radicals.