EFFECT OF EPIVAL ON THE CHANGES IN BONE MINERAL LEVEL IN CHILDREN

Abstract

Objective: To assess the mean change in bone mineral level in children with treatment of epival for management of epilepsy

Study Design: Quasi experimental study

Material and Method: The present study was carried out in the Paediatric department, Services hospital Lahore. Duration of study was 6 months from 02-03-2017 to 02-09-2017. 110 children suffering from epilepsy and taking epival were enrolled in the study from OPD of Department of Pediatrics, Services Hospital, Lahore. Informed consent was obtained from parents. Demographic profile (name, age, gender, address and contact) were also noted. Their blood samples were collected for assessing serum ALP and calcium. Reports were assessed and baseline values were noted. Children were followed-up in OPD for 90 days. After 90 days, calcium and ALP were assessed again. All this information will be recorded in pre-designed proforma. Data was analyzed by using SPSS-20 software.

Results: The results showed that average age of children was 7.68±4.05years. There were 56(50.91%) males while 54(49.09%) females. The mean BMI of patients was 22.40±2.60kg/m2. The mean calcium level at baseline was 9.34±0.53mg/dl which was decreased to 8.56±0.77mg/dl after 09 days of treatment with epival. The mean change in calcium was 0.78±0.43mg/dl which was significant (P<0.05). The mean ALP level at baseline was 96.20±30.47U/L which was increased to 118.07±38.41U/L after 09 days of treatment with epival. The mean change in ALP level was 21.87±9.38U/L which was significant (P<0.05).

Conclusion: There is significant impact of epival on bone mineral density of epileptic children