COMPARISON OF RECTALLY ADMINISTERED MISOPROSTOL AND OXYTOCIN INFUSION FOR MANAGEMENT OF 3RD STAGE OF LABOUR IN 2ND TRIMESTER PREGNANCY LOSS

Abstract

Misoprostol and oxytocin are two common medications used to prevent PPH and other pregnancy related complications, particularly in pregnancy loss. Both of these drugs can be administered through different routes and have different effectiveness. So this study was done to compare the effectiveness of these drugs.

Objective: To compare the outcome of rectally administered misoprostol and oxytocin infusion for management of 3rd stage of labour in 2nd trimester pregnancy loss.

Material & Methods: The randomized control trial was conducted at department of Obstetrics and Gynaecology, Lady Willingdon Hospital, Lahore. Then patients were randomly divided into two groups by using lottery method. In group A, 600 μg tablets of misoprostol was used rectally at the time of delivery of foetus. In group B, 20 IU of oxytocin was given I/V infusion at the time of delivery of foetus. For comparison independent sample t-test was used to compare blood loss in both study groups. P-value<0.05 was taken as significant.

Results: In our study the mean age of the patients was 27.35±6.35 years and the mean gestational age was 18.21±3.95 weeks, the mean blood loss was 369.28±87.26 ml. Retained placenta was observed in 48(17.1%) patients and the PPH was found in 15% patients. Statistically there is significant difference was observed between the study groups and retained placenta of the patients i.e. p-value=0.011.

Conclusion: The results of our study concluded that the use of misoprostol is an effective and feasible drug in blood loss, PPH and Retained placenta as compared to oxytocin drug in the managmenet of 3rd stage of labour in 2nd trimester pregnancy loss