PAIN SCORE IN NEONATES WHILE ADMINISTERING SURFACTANT VIA LISA METHOD WITH AND WITHOUT PREMEDICATION WITH OPIOID AND ATROPINE.

  • Abeer Asif CMH Quetta
  • Hina Batool Siddiqui PAF Hospital
  • Hina Muhammad Ali CMH Quetta
  • Muhammad Shoaib CMH Quetta
  • Samrina Yasmeen CMH Quetta
  • Hareem Abrar Hashmi CMH Quetta
Keywords: lisa, opioid, pain score, surfactant

Abstract

Objective: To determine the Pain score in neonates while administering surfactant via LISA method with and without premedication with opioid and atropine.

Study Design: Quasi experimental study

Place and duration of Study: This quasi experimental study was conducted in neonatology unit of CMH Quetta from Feb 2024 to Dec 2024.

Methodology: Inclusion criteria was spontaneously breathing preterm neonates who were <35 weeks of gestation diagnosed as RDS within first 48 hours of life. Premedication with nalbuphine at 0.05mg/kg and atropine 20microg/kg was used in intervention group. The surfactant  Curosurf (200 mg/kg body weight) was instilled intratracheally via the feeding tube. Pain score was assessed by NIPS (neonate infant pain score)

Results: Total 50 preterm neonates were included. Out of these 25 patients were given LISA with premedication and 25 were given LISA without any premedication. There were 26 (52%) male neonates and female neonates. The mean gestational age at birth was  30.68 + 3.67 weeks. Mean pain score in group A was 2.90 + 2.09 before LISA and after medication it reduced to 2.04 + 1.64 (p value 0.001) while mean pain score in group B was 1.92 + 1.08 which increased to 3.00 + 1.61 after LISA.

Conclusion: Nalbuphine and atropine in low dose is effective in managing pain and discomfort during LISA in pre term neonates with less post procedural complications.

Author Biographies

Hina Batool Siddiqui, PAF Hospital

Assistant Professor

Hina Muhammad Ali, CMH Quetta

Fellow Neonotology

Muhammad Shoaib, CMH Quetta

Assistant Professor

Samrina Yasmeen, CMH Quetta

Resident Pediatric

Hareem Abrar Hashmi, CMH Quetta

Resident Pediatrics

Published
2025-10-01