FREQUENCY TO ANTI-HBS ANTIBODY POSITIVITY (≥ 10 mlU/ml) IN CHILDREN AGED 5-10 YEARS AFTER HEPATITIS B VACCINATION IN INFANCY

  • Hina Batool Siddiqui Pakistan Aeronautical Complex Hospital Kamra
  • Nighat Haider Associate Professor of Pediatrics, PIMS, Islamabad
  • Madeeha Ikram Pediatrician, KRL Hospital, Islamabad.
  • Nasreen Ali Assistant Professor of Pediatrics, Fazia Medical College
  • Abeer Asif Senior Registrar Pediatrics, CMH Quetta.
  • Sehreen Imran Registrar Rawal Institute of Health Sciences, Islamabad.
DOI: https://doi.org/10.51642/ppmj.v35i03.699
Keywords: HBV, HBV vaccine, Anti HBsAg titer

Abstract

BACKGROUND: Hepatitis B is an infection of liver by hepatitis B virus (HBV) which is potentially fatal. The response of hepatitis B vaccine can be seen after 6-8 weeks of immunization and the child is considered protected when he has anti-HBS levels ≥ 10mIU/ml. however few studies have shown that response of hepatitis B vaccination diminishes overtime.

OBJECTIVES: To determine the frequency to anti- HBS antibody positivity (≥10mIU/ml) in children aged 5-10 years after hepatitis B vaccination in infancy.

STUDY DESIGN: Cross-sectional Study

SETTING: Department of Pediatrics, PAC Hospital Kamra

DURATION OF STUDY: 6 months

RESULTS: My study was conducted on 343 cases. Mean age was 7.4606 ± 1.80741 years (minimum was 5 and maximum was 10 years) 47.8% cases had titer less than 10, 43.1% had equal to or more than 10 and 9% had titer equal to or more than 100. 52.2% had immune status positive and 47.8 had negative status.

CONCLUSION: Although majority of our cases were immune to HBV infection but difference was only minor when compared to numbers in non-immune group. After EPI vaccination; immune status was found to be more retained in females as compared to males.HBV

Author Biography

Hina Batool Siddiqui, Pakistan Aeronautical Complex Hospital Kamra

Assistant Professor of Pediatrics

Published
2024-12-04
Issue
Vol 35 No 03 (2024): Pakistan Postgraduate Medical Journal
Section
Article