MEAN SERUM LIPID LEVELS AMONG PATIENTS WITH MILD VERSUS SEVERE ECLAMPSIA

Abstract

Background: Pre-eclampsia (PE) is a condition of high blood pressure in pregnancy and also having protein in urine. Preeclampsia is known to be a common disorder with vascular endothelial level malfunction , along with vasospasm which occurs after , twenty weeks of pregnancy, but it can also occur , as late as 4 to 6 weeks postpartum. There is a controversy in serum lipids levels among patients with mild or severe preeclampsia however, abnormality in lipid profiles exists in patients with preeclampsia. So we have conducted this study, to find out the serum lipid profile of patients with PE.

Objective: To compare the mean serum lipid levels, among the patients with mild versus severe pre-eclampsia (PE).

Material &Methods: This is a descriptive case series study. It was carried out at Obs and Gynae Dept of Lahore General Hospital for six months. 320 pregnant females with PE were selected by non-probability, purposive sampling type technique. The patients were then categorized out into the mild or severe types of pre-eclampsia. The Fasting venous blood sample of 5cc was taken in a disposable sterilized syringe and we sent to the laboratory of Lahore General Hospital, Lahore. The laboratory reports of serum lipid profiles were compared for any differences present between the 2( mild and severe). Student t-test was used for comparing the mean of serum lipid levels between the two categories of preeclampsia (mild or severe) . P-value less than 0.05 was to be taken as a significant value.

Results: In our study the patient’s mean age was 24.79±3.89-year, mean BMI of the patients was 25.23±3.89 kg/m2, obesity was observed in 30.63% patients. Mild preeclampsia was observed in 83.1% patients and severe preeclampsia was observed in 16.9% patients. Statistically highly significant differences were seen between the mean TC, TG and HDL levels with the severity of PE. Conclusion: Our study results lead us to the conclusion that the patients with mild pre-Eclampsia had lower levels of LDL, TG, and TC compared with severe PE patients, while HDL value was found higher in females with mild PE as compared with severe PE.