COMPARISON OF EFFICACY OF NEPAFENAC 0.3% AND NEPAFENAC 0.1% TO PREVENT AND CONTROL POSTOPERATIVE PAIN AND CONJUNCTIVAL REDNESS AFTER CATARACT SURGERY: A RANDOMIZED CONTROL TRIAL

  • Saira Jabeen Postgraduate Resident (Ophthalmology), Gujranwala Medical College/ DHQ Hospital, Gujranwala
  • Zeeshan Hameed Postgraduate Resident (Ophthalmology), Gujranwala Medical College/ DHQ Hospital, Gujranwala https://orcid.org/0000-0001-5718-8073
  • Bazla Batool Postgraduate Resident (Ophthalmology), Gujranwala Medical College/ DHQ Hospital, Gujranwala
  • Irfan Qayyum Malik Associate Professor/ HOD Ophthalmology, Gujranwala Medical College/ DHQ Hospital, Gujranwala
  • Aamna Jabran Assistant Professor Ophthalmology, Gujranwala Medical College/ DHQ Hospital, Gujranwala
  • Abdullah Younas Consultant Ophthalmologist, Ibrahim Trust Eye Hospital, Gujranwala
DOI: https://doi.org/10.51642/ppmj.v32i03.456
Keywords: Nepafenac, Postoperative Pain, Conjunctival Redness, Cataract Surgery

Abstract

Purpose: To compare the efficacy of nepafenac 0.3% with nepafenac 0.1% to control postoperative pain and conjunctival redness after cataract surgery.

Study Design: Randomized control trial

Place and Duration: Ophthalmology Department, DHQ Teaching Hospital, Gujranwala from November 2020 to January 2021.

Materials and Methods: A prospective review of 70 patients operated for age-related cataract was done. Patients were divided into two equal groups. Group A patients were given Ilevro eye drops (nepafenac 0.3%) once a day and group B patients were instilled Nevanac eye drops (nepafenac 0.1%) thrice a day. All patients were scored for ocular pain and conjunctival redness on basis of pre-defined scales on one day before surgery and on 1st, 7th and 14th postoperative day. Results from both groups were analyzed and compared using SPSS v 25.0.

Results: Out of 70 patients, 35 were put in group A and 35 into group B. Overall 37 (52.8%) patients were male and 33 (47.2%) were female. Patients above 40 years of age were 33 (94.3%) in group A and 35 (100%) in group B. Patients having pain score ≥5 were 30 (85.7%) in group A and 25 (71.4%) in group B on 1st postoperative day, with ≥3 were 1 (2.8%) in group A and 33 (94.2%) in group B at 7th postoperative day and zero on 14th postoperative day. Patients with conjunctival redness ≥2 were 31 (88.6%) in group A and 29 (82.9%) in group B on 1st postoperative day, with ≥1 were 18 (51.3%) in group A and 28 (79.9%) in group B on 7th postoperative day while four (11.4%) in group A and one (2.8%) in group B on 14th postoperative day.   
Conclusion: Effect of once daily nepafenac 0.3% on postoperative pain and conjunctival redness was found to be sub-rated against thrice daily nepafenac 0.1% on 1st postoperative day. However, this effect became equal and then slightly superior to that of nepafenac 0.1% on 7th and 14th postoperative days.

Key Words: Cataract Surgery, Nepafenac, Postoperative Pain, Conjunctival Redness

Published
2022-03-30
Issue
Vol 32 No 03 (2021): Pakistan Postgraduate Medical Journal
Section
Article