PROTECTIVE EFFECT OF CORIANDRUM SATIVUM L. (CORIANDER) ETHANOLIC LEAF EXTRACT ON ISONIAZID INDUCED HEPATOTOXICITY IN ALBINO MICE

Abstract

Objective:  To study the antioxidant effects of ethanolic extract of coriander leaves on INH induced hepatotoxicity.

Methods: Total 27 male albino mice were randomly divided through balloting into three groups containing nine animals each. Group A served as control while INH toxicity was produced by oral administration (INH 100mg/kg) to group B. Hepatoprotectivity was investigated by co-administration of single oral dose of ethanolic extract of coriander leaves (200mg/kg) along with INH in groups C for 30 days.

Results: On gross examination, liver of group C animals were found to be normal. Biochemical analysis of liver markers of group B showed that these enzymes were markedly raised while experimental group C showed significant decreased level of liver enzymes. Histological examination of group C revealed normal histology with little evidence of inflammation, vascular congestion, necrosis, pyknosis, apoptosis and vacuolar degeneration as compared to group B.  

Conclusion: This study showed the ameliorating effect of ethanolic extract of Coriandrum sativum L. against INH induced hepatotoxicity.