PROTECTIVE EFFECT OF CORIANDRUM SATIVUM L. (CORIANDER) ETHANOLIC LEAF EXTRACT ON ISONIAZID INDUCED HEPATOTOXICITY IN ALBINO MICE

HEPATOPROTECTIVE EFFECT OF CORIANDER

  • Mohtasham Hina Rawalpindi medical University, Rawalpindi
  • Ammara Rasheed Nishtar Medical University, Multan
  • Maria Tasleem Rawalpindi medical University, Rawalpindi
  • Nadia Naseem University of Health sciences, Lahore
Keywords: hepatoprotection, coriander, isoniazid, hepatotoxicity

Abstract

Objective:  To study the antioxidant effects of ethanolic extract of coriander leaves on INH induced hepatotoxicity.

Methods: Total 27 male albino mice were randomly divided through balloting into three groups containing nine animals each. Group A served as control while INH toxicity was produced by oral administration (INH 100mg/kg) to group B. Hepatoprotectivity was investigated by co-administration of single oral dose of ethanolic extract of coriander leaves (200mg/kg) along with INH in groups C for 30 days.

Results: On gross examination, liver of group C animals were found to be normal. Biochemical analysis of liver markers of group B showed that these enzymes were markedly raised while experimental group C showed significant decreased level of liver enzymes. Histological examination of group C revealed normal histology with little evidence of inflammation, vascular congestion, necrosis, pyknosis, apoptosis and vacuolar degeneration as compared to group B.  

Conclusion: This study showed the ameliorating effect of ethanolic extract of Coriandrum sativum L. against INH induced hepatotoxicity.

Author Biographies

Mohtasham Hina, Rawalpindi medical University, Rawalpindi

Assistant professor

Ammara Rasheed, Nishtar Medical University, Multan

Assistant professor

Maria Tasleem, Rawalpindi medical University, Rawalpindi

Assistant professor

Nadia Naseem, University of Health sciences, Lahore

Professor, Morbid Anatomy and Histopathology,

Published
2022-03-30