FASTING SERUM RESISTIN AND BLOOD GLUCOSE LEVELS IN NEWLY DIAGNOSED MALE PATIENTS OF PULMONARY TUBERCULOSIS WITH AND WITHOUT DIABETES MELLITUS TYPE 2

Abstract

The aim of this cross-sectional comparative study was to determine and compare fasting serum resistin and fasting blood glucose (FBG) level in the newly diagnosed pulmonary tuberculosis (TB) patients having and not having diabetes mellitus type 2 (DM). Eighty four male subjects were divided equally into groups. Group 1, healthy controls (n=28), group 2, newly diagnosed patients of pulmonary tuberculosis without DM (n=28) and group 3 included new pulmonary TB patients with newly diagnosed DM type 2 (n=28). Serum resistin and fasting blood glucose levels were determined before starting anti-TB and hyperglycemia treatment.Severity of TB was determined by analysis of sputum for bacterial load. Fasting serum resistin was done by ELISA and fasting blood Glucose by a glucose oxidase kit. Fasting blood glucose showed a significant difference between the three study groups (p= 0.000). Fasting serum resistin levels did not show a statistically significant (p= 0.098) difference between the groups. However a significant difference in serum resistin levels (p= 0.029) was observed when the TB patients were divided according to sputum smear analysis reports. Disease severity can influence serum resistin levels. Hyperglycemia present in the TB non-diabetic patients before starting ATTshould be taken into consideration.