PREVALENCE OF PULMONARY HYPERTENSION IN PATIENTS UNDERGOING REGULAR MAINTENANCE HEMODIALYSIS DUE TO END STAGE RENAL DISEASE
Objectives: To determine the prevalence of pulmonary hypertension (PH) in patients undergoing regular hemodialysis (HD) via arteriovenous access due to end stage renal diseae (ESRD) and correlation of PH with variables such as Age, Gender, Body mass index, Hypertension, Diabetes, duration of dialysis, hemoglobin (HB) concentration.
Methodology: The type of study is a Cross sectional study that was conducted In Nephrology Department, Lahore General Hospital, Pakistan over a period of 6months, From July 2016, to Dec, 2016 in Age group 16yrs to 65yrs old Population, taking into consideration the inclusion & exclusion criteria and appropriate informed consent after taking detailed history of every patient. The study population consisted of n=50 with end stage renal disease. Various parameters including the Pulmonary Arterial systolic pressure (PASP) were recorded. A pulmonary arterial pressure greater than 25mmHg at rest was defined as pulmonary hypertension, and it was further divided into three sub categories mild (btw 25-40mmHg), moderate (btw 40-55mmHg) and severe (greater than 55mmHg). Data were correlated with different variables like Age, Gender, Body mass index, Hypertension, Diabetes, Duration of dialysis, HB concentration. Data was analyzed using SPSS v23.0. Results: Out of the Total n=50 patients, 28(56%) were males and 22(44%) were females. The mean duration of time duration of dialysis was 14.88±9.87 months. 18(36%) patients were found to have PH, 32(64%) did not have PH. Pulmonary hypertension was found to be greater in patients who had been on dialysis for more than 5 months. It was also noticed that longer the duration of Hemodialysis, greater the prevalence of PH. Our study revealed a positive association between the duration of dialysis and the prevalence of PH along-with low levels of hemoglobin with mean 10.02± 2.12 and high body mass index with mean 24.0±6.62.
Conclusion: According to the results of our study patients on maintenance hemodialysis due to end stage renal disease ,the prevalence of PH is more common in males and has a strong correlation with the duration of maintenance hemodialysis, body mass index, old age group (46-65yrs), Diabetes, Hypertension and low HB concentration.