INDUCTION OF LABOUR WITH MISOPROSTOL VERSUS PROSTAGLANDIN E2 IN AN ALIVE TERM FETUS

Abstract

Objective: The objective of this study was to compare efficacy of misoprostol with PGE2 for induction of labor in an alive term fetus.

Materials And Methods: This study was conducted in Department of obstetrics and gynecology unit III, Nishtar Hospital Multan from 9th October, 2013 to 8th April, 2015. One hundred and fifty four patients at term were included in this randomized controlled trial. Final outcome i.e. successful vaginal delivery was confirmed at the end of 6 hours after giving the maximum dose of either medicine. Statistical analysis was performed using SPSS v17. P-value of ≤ 0.05 was taken as statistically significant.

Results: Mode of delivery in both groups revealed that 12.99% (n=10) in Group-A and 38.96% (n=30) in Group-B had cesarean delivery and 87.01% (n=67) in Group-A and 61.04% (n=47) in Group-B had normal vaginal delivery, p value was calculated as <0.001 which was significant. Efficacy in both groups revealed that in 12.99% (n=10) patients from Group-A and in 38.96% (n=30) patients from Group-B, the drug failed to show efficacy and in 87.01% (n=67) patients from Group-A and in 61.04% (n=47) patients from Group-B the respective drugs were efficacious, p value was calculated as <0.001.

Conclusion: The results of the study conclude that compared to PGE2, misoprostol has superior efficacy.