COMPARISON OF URINARY KIDNEY INJURY MOLECULE1/CREATININE RATIO IN PATIENTS WITH RENAL STONE SIZE 5 MM - 20 MM

  • DR. MUNAZZA YASMEEN Postgraduate Medical Institute, Lahore
  • dr. SUMBLA GHAZNAVI Postgraduate Medical Institute, Lahore
  • DR. HAFIZ MOHAMMAD KHALID MEHMOOD Postgraduate Medical Institute, Lahore
  • DR. NADIA AWAN Postgraduate Medical Institute, Lahore
Keywords: KIM-1, Urolithiasis, Renal Injury, Creatinine

Abstract

Introduction: Urolithiasis ( stone formation in urine) is a common disease that affects the excretory system of urine in all age groups. Urolithiasis may be associated with complications such as infection, obstructive uropathy leading to acute renal failure, chronic kidney damage and in the worst scenario, to the loss of a kidney.

Methodology: In this study, KIM-1 was measured in patients who were divided into three groups - A comprising controls(without renal stone), B contained patients each of whom having been suffering from renal stone size 5 to 10.9mm, C composed of patients having renal stone size 11 to 20mm. Each group contained 28 subjects with age ranging from 20 to 40years. Urinary KIM-1 levels was normalized by urinary creatinine in spot urine. KIM1/Creatinine ratio in urine was expressed as (ng/mg).KIM-1/Creatinine ratio. It is a cross sectional, comparative study. Creatinine was estimated by jaffes method. Urine KIM-1 was determined in urine sample by ELISA method on semi-automated ELISA instrument .

Results: Our results showed that urinary KIM-1 creatinine ratio was significantly raised in patients suffering from renal stone than control group.

Conclusion: Our results proposes that urinary KIM-1is likely to become a useful biomarker for kidney injury associated with smallest renal stones. The significance relies not only in the possibility of identifying a urinary marker of injury, but also in the ability to measure the grade of renal injury allowing for modification of treatment paradigm.

Published
2015-09-01