EFFECTS OF DEXAMETHASONE ON LIVER HISTOLOGY OF ADULT ALBINO MICE

Abstract

Objective: In this study the effects of dexamethasone on liver histology in animal model were evaluated.

Design: This study comprised of 120 albino adult mice which were divided in four groups; one control and three experimental groups (on ascending doses of dexamethasone) administered for twelve weeks. The mice were sacrificed at 4, 8 and 12 weeks and liver histology was examined. The liver was serially sectioned and stained with Haematoxylin and Eosin stains. A comparison of any dose-related changes of dexamethasone on the liver was made with the control group. One way ANOVA was applied to compare weight of liver, size of hepatocyte and nuclear changes in all groups.

Results: Histological analysis showed that dexamethasone induced increase in weight of liver, an increase in hepatocyte size in relation to the dose given. Nuclear changes showed pyknosis with heightened staining. Cellular infiltration and portal vein congestion.

Conclusion: These findings suggest thatdexamethasone has deleterious effects on liver histology.