ASSOCIATION OF IRON DEFICIENCY ANEMIA IN PATIENTS WITH CHRONIC RENAL FAILURE

ALIYA ASLAM; QUNDEEL ZAHRA; SADIA IKRAM; IKRAM-UL-HAQ; SADIA SAJJAD; `MUHAMMAD BILAL

doi:10.51642/ppmj.v27i4.112

DR. ALIYA ASLAM Postgraduate Medical Institute, Lahore
DR. QUNDEEL ZAHRA Postgraduate Medical Institute, Lahore
DR. SADIA IKRAM Postgraduate Medical Institute, Lahore
DR. IKRAM-UL-HAQ Postgraduate Medical Institute, Lahore
DR.SADIA SAJJAD Continental Medical College, Lahore
DR. MUHAMMAD BILAL Azra Naheed Medical College, Lahore

DOI: https://doi.org/10.51642/ppmj.v27i4.112

Keywords: Anemia, Iron Status, Chronic Renal Failure, Hepcidin

Abstract

Objectives: To find out the probable association of iron deficiency anemia in patients with chronic renal failure and to find out serum hepcidin and hemoglobin levels with iron and inflammation status in patients of chronic renal failure

Study Design: Cross sectional study

Place and Duration of Study: Social Security Teaching Hospital Lahore from 1st March 2016 to 30th September 2016.

Materials and Methods: A total of 50 patients were included. Serum hepcidin, ferritin, high sensitivity C-reactive protein and iron levels were measured using standard methods. Statistical correlations were established.

Results: There were 15 (30%) females and 35 (70%) males with mean age of 50.55±14.4 years. A significant correlations was seen between hepcidin with iron status, nutritional and inflammatory markers such as ferritin, total iron binding capacity and albumin (p<0.05 respectively). An inverse relationship was seen between hepcidin and hemoglobin levels (p<0.05)

Conclusion: A negative correlation of hepcidin with hemoglobin level in these patients with inadequate iron stores, which could be effective in the development of an anemia in such patients.