OUTCOME OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS DIAZEPAM FOR CONTROL OF ACUTE SEIZURES
Objective: To compare midazolam and diazepam given via intramuscular and intravenous route respectively for management of fits in children presenting in emergency.
Study Design: Randomized controlled study
Place and Duration: This study was conducted in Paediatrics Emergency, Ittefaq Trust Hospital, Lahore from 24th June 2013 to 23rd December 2013.
Materials and Methods: In this study we took 60 cases and assigned them group A and B (30 cases in each group). Group A was given 0.2mg/kg/dose midazolam via intramuscular route and group B was given intravenous diazepam (0.2mg/kg/dose)for management of fits.
Results: Mean age was 2.59±2.88 and 3.55±3.09 years in group A and B respectively. Group A and B included 17 (56.7%) &18 (60%) males respectively while there were 13 (43.3%) and 12 (40%) females in group-A and B respectively. It was observed that in Group A (I/M midazolam) time interval was significantly less as compared to Group-B (I/v diazepam) (5.89±2.63 vs 8.35±2.88 minute) p<0.001 for control of seizure (minutes).
Conclusion: Intramuscular midazolam is effective in controlling acute seizures significantly as compared to intravenous diazepam.